antigen

noun

: any substance (such as an immunogen or a hapten) foreign to the body that evokes an immune response either alone or after forming a complex with a larger molecule (such as a protein) and that is capable of binding with a product (such as an antibody or T cell) of the immune response

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An antibody is a protein produced by your immune system to fight outside invaders. Since the enemy substance actually triggers the production of antibodies, such substances are called antigens—anti- being short for antibody, and -gen meaning "producer". (In a similar way, an allergen produces an allergy, and a pathogen produces a pathology or disease.) Antigens are often rodlike structures that stick out from the surface of an invading organism—usually a bacterium or a virus—and allow it to attach itself to cells in the invaded body. But unfortunately for them, in doing so they let the immune system know they're present, and the body is flooded with an army of Pac-Man-like antibodies.

Examples of antigen in a Sentence

Recent Examples on the Web
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Does the alpha-gal in a tick’s saliva piggyback on some virus or antigen that sensitizes people to it? Burkhard Bilger, New Yorker, 29 June 2026 An antigen is the active ingredient in a vaccine that triggers an immune response in humans. Will McCurdy, PC Magazine, 6 June 2026 An antigen is the active ingredient in a vaccine meant to trigger an immune-system response and fight off infection. Teresa Mull, FOXNews.com, 13 June 2026 Giles, like sports officials around the globe, became an expert on antigen tests, contact tracing and incubation periods. Matt Slater, New York Times, 9 May 2026 See All Example Sentences for antigen

Word History

Etymology

German, from French antigène, from anticorps antibody + -gène -gen

First Known Use

1908, in the meaning defined above

Time Traveler
The first known use of antigen was in 1908

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Cite this Entry

“Antigen.” Merriam-Webster.com Dictionary, Merriam-Webster, https://www.merriam-webster.com/dictionary/antigen. Accessed 7 Jul. 2026.

Kids Definition

antigen

noun
: a substance (as a protein) that causes the body to form antibodies against it when it is introduced into the body either alone or as part of a microscopic plant or animal

Medical Definition

antigen

noun
: any substance (as an immunogen or a hapten) foreign to the body that evokes an immune response either alone or after forming a complex with a larger molecule (as a protein) and that is capable of binding with a product (as an antibody or T cell) of the immune response

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