1
a(1)
: the outer or superficial part of an organ or bodily structure (such as the kidney, adrenal gland, or cerebellum or a bone)
especially : cerebral cortex
(2)
: the proteinaceous usually pigmented layer of a hair below the cuticle
b
: the outer part of some organisms (such as paramecia)
2
: a plant bark or rind (such as cinchona) used medicinally
3
a
: the typically parenchymatous layer of tissue external to the vascular tissue and internal to the corky or epidermal tissues of a green plant
broadly : all tissues external to the xylem
b
: an outer or investing layer of various algae, lichens, or fungi

Examples of cortex in a Sentence

Recent Examples on the Web
Examples are automatically compiled from online sources to show current usage. Read More Opinions expressed in the examples do not represent those of Merriam-Webster or its editors. Send us feedback.
This shampoo, for instance, contains salicylic acid to gently exfoliate and stimulate the scalp as well as strengthening molecules that penetrate deep into the cortex to minimize breakage. — Ellie Davis, Vogue, 22 Oct. 2026 If eating a Reese’s Peanut Butter Pumpkin sends you back to nights in elementary school sorting candy on your living room floor, that memory formed by passing through your brain’s gustatory cortex, which handles taste. — Helen Carefoot, Flow Space, 22 Oct. 2026 This wireless device provides a broad 6-millimeter field of view across the cortex. — Mrigakshi Dixit, Interesting Engineering, 21 Oct. 2026 Friston and his colleagues have found in studies across species that important brain circuits throughout the cortex seem to be wired to match information from the senses with data from memory to make predictions. — Maia Szalavitz, Scientific American, 20 Oct. 2026 See All Example Sentences for cortex

Word History

Etymology

Latin cortic-, cortex bark — more at cuirass

First Known Use

circa 1676, in the meaning defined at sense 1a(1)

Time Traveler
The first known use of cortex was circa 1676

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Cite this Entry

“Cortex.” Merriam-Webster.com Dictionary, Merriam-Webster, https://www.merriam-webster.com/dictionary/cortex. Accessed 1 Nov. 2026.

Kids Definition

1
: an outer or surrounding layer of an organ or body part
the cortex of the kidney
especially : the outer layer of gray matter of the cerebrum
2
: the layer of tissue outside the xylem and phloem and inside the corky or epidermal tissues of a vascular plant
also : all tissues external to the xylem

Medical Definition

1
a
: the outer or superficial part of an organ or body structure (as the kidney, adrenal gland, or a hair)
especially : cerebral cortex
b
: the outer part of some organisms (as paramecia)
2
a
: a plant bark or rind (as cinchona) used medicinally
b
: the peel of any of several fruits
—used especially in the writing of medical prescriptions

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