hydroxyzine

noun

hy·​droxy·​zine hī-ˈdräk-sə-ˌzēn How to pronounce hydroxyzine (audio)
: a compound C21H27ClN2O2 used as an antihistamine and tranquilizer

Examples of hydroxyzine in a Sentence

Recent Examples on the Web
Examples are automatically compiled from online sources to show current usage. Read More Opinions expressed in the examples do not represent those of Merriam-Webster or its editors. Send us feedback.
And so can one specific antihistamine, hydroxyzine. — Bruce Y. Lee, Forbes.com, 15 May 2025 While both hydroxyzine and Benadryl are commonly used for seasonal allergies and allergic reactions, only hydroxyzine is approved to treat anxiety. — Jessica Swirble, Verywell Health, 11 Feb. 2025 First-generation oral antihistamines, like Benadryl (diphenhydramine) or Atarax (hydroxyzine), are more likely than second-generation antihistamines, like Claritin (loratadine) or Zyrtec (cetirizine), to cause drowsiness, Yu said. — Hannah Seo, San Diego Union-Tribune, 2 Apr. 2024 The doctor gave her hydroxyzine, an antihistamine with a sedative effect; paracetamol, a medication used to reduce fever; and an antibiotic, according to medical records obtained by Krzysztof and reviewed by TIME. — TIME, 13 Oct. 2023 See All Example Sentences for hydroxyzine

Word History

Etymology

hydroxy- + piperazine

First Known Use

1956, in the meaning defined above

Time Traveler
The first known use of hydroxyzine was in 1956

Rhymes for hydroxyzine

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Browse Nearby Words

hydroxyurea
hydroxyzine
hydrozincite
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Cite this Entry

“Hydroxyzine.” Merriam-Webster.com Dictionary, Merriam-Webster, https://www.merriam-webster.com/dictionary/hydroxyzine. Accessed 8 Jul. 2026.

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Medical Definition

hydroxyzine

noun
hy·​droxy·​zine hī-ˈdräk-sə-ˌzēn How to pronounce hydroxyzine (audio)
: a compound that is administered usually in the form of its dihydrochloride C21H27ClN2O2·2HCl or pamoate C21H27ClN2O2·C23H16O6 and is used as an antihistamine and tranquilizer see vistaril
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