methotrexate
noun
meth·o·trex·ate
ˌme-thə-ˈtrek-ˌsāt 
: a toxic folic acid analog C20H22N8O5 that is used to treat certain cancers, severe psoriasis, and rheumatoid arthritis
Examples of methotrexate in a Sentence
Recent Examples on the Web
The protocol required that methotrexate be administered three or in some cases seven days prior to the misoprostol, rather than the typical 24-48 hours between mifepristone and misoprostol.
—
Christine Henneberg,
STAT,
15 May 2026
Such an impairment can occur as a side effect of certain chemotherapy drugs, such as methotrexate.
—
ArsTechnica,
10 Mar. 2026
Examples include amiodarone, methotrexate, and black cohosh.
—
Health,
15 Dec. 2025
The case for leucovorin Until now, leucovorin has been prescribed primarily to protect healthy cells from the toxic effects of methotrexate, a common chemotherapy drug used in cancer care.
—
Jon Hamilton,
NPR,
25 Sep. 2025
See All Example Sentences for methotrexate
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Christine Henneberg,
STAT,
15 May 2026
Such an impairment can occur as a side effect of certain chemotherapy drugs, such as methotrexate.
—
ArsTechnica,
10 Mar. 2026
Examples include amiodarone, methotrexate, and black cohosh.
—
Health,
15 Dec. 2025
The case for leucovorin Until now, leucovorin has been prescribed primarily to protect healthy cells from the toxic effects of methotrexate, a common chemotherapy drug used in cancer care.
—
Jon Hamilton,
NPR,
25 Sep. 2025
See All Example Sentences for methotrexate
Cite this Entry
“Methotrexate.” Merriam-Webster.com Dictionary, Merriam-Webster, https://www.merriam-webster.com/dictionary/methotrexate. Accessed 7 Jul. 2026.
Copy CitationMedical Definition
methotrexate
noun
meth·o·trex·ate
ˌmeth-ə-ˈtrek-ˌsāt
: a toxic drug C20H22N8O5 that is an analog of folic acid and is used to treat certain cancers, severe psoriasis, and rheumatoid arthritis
called also amethopterin
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