variants or less commonly pain-killer
Synonyms of painkillernext
: something (such as a drug) that relieves pain
pain-killing adjective
or painkilling

Examples of painkiller in a Sentence

I took some over-the-counter painkillers for my headache. after her oral surgery, she was given a prescription for a mild painkiller
Recent Examples on the Web
Examples are automatically compiled from online sources to show current usage. Read More Opinions expressed in the examples do not represent those of Merriam-Webster or its editors. Send us feedback.
None of that stupid drug story stuff or anything other than factual things about painkiller addiction. Lily Moayeri, SPIN, 25 June 2026 Police officers found two hydrocodone pills, a prescription painkiller, in his pocket. Gabby Herzig, New York Times, 23 June 2026 He was arrested on a DUI charge in Florida in late March — painkillers were found in his pocket but no alcohol in his system — and sought treatment outside the country. ABC News, 23 June 2026 Cathy says her daughter's addiction struggles began after a 2016 motorcycle accident, when doctors prescribed her painkillers. Gillian Telling, PEOPLE, 24 June 2026 See All Example Sentences for painkiller

Word History

First Known Use

1849, in the meaning defined above

Time Traveler
The first known use of painkiller was in 1849

Browse Nearby Words

Cite this Entry

“Painkiller.” Merriam-Webster.com Dictionary, Merriam-Webster, https://www.merriam-webster.com/dictionary/painkiller. Accessed 7 Jul. 2026.

Kids Definition

painkiller

noun
: something (as a drug) that relieves pain

Medical Definition

painkiller

noun
: something (as a drug) that relieves pain

More from Merriam-Webster on painkiller

Love words? Need even more definitions?

Subscribe to America's largest dictionary and get thousands more definitions and advanced search—ad free!