1
2
: the base on which an organism lives
the soil is the substrate of most seed plants
3
: a substance acted upon (as by an enzyme)

Did you know?

With its Latin prefix sub-, "below", substrate obviously refers to a layer under something else. Rock may serve as the substrate for the coral in a coral reef. Tiny wafers of silicon (or another semiconductor) serve as the substrate for computer chips. Substrate may also mean subsoil—that is, the layer under the topsoil, lacking in organic matter or humus. Substrate is part of the vocabulary of various other sciences, including chemistry and biology. But although it's mostly a scientific term, writers may also use it to mean simply "foundation"—for instance, when observing that reading is the substrate on which most other learning is based.

Examples of substrate in a Sentence

Recent Examples on the Web
Examples are automatically compiled from online sources to show current usage. Read More Opinions expressed in the examples do not represent those of Merriam-Webster or its editors. Send us feedback.
The team then fabricated their surface on a glass substrate. IEEE Spectrum, 18 June 2026 For instance, inside the skunks’ pen, a cat litter box was filled with dirt, leaves and other natural substrate. Caleb Lunetta, San Diego Union-Tribune, 8 July 2026 Workflows should be rebuilt around AI as the default substrate, not the latest tool added on. Abe Ankumah, Forbes.com, 2 July 2026 However, these bog plants require a moist substrate to thrive, says Crumbley. Helena Madden, Martha Stewart, 23 June 2026 See All Example Sentences for substrate

Word History

Etymology

Medieval Latin substratum

First Known Use

1730, in the meaning defined at sense 1

Time Traveler
The first known use of substrate was in 1730

Browse Nearby Words

Cite this Entry

“Substrate.” Merriam-Webster.com Dictionary, Merriam-Webster, https://www.merriam-webster.com/dictionary/substrate. Accessed 10 Jul. 2026.

Kids Definition

1
: an underlying layer: as
b
: the base on which an organism lives or over which it moves
the soil is the substrate of most plants
2
: a substance acted upon (as by an enzyme)

Medical Definition

1
2
: the base on which an organism lives
3
: a substance acted upon (as by an enzyme)

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