: a phenothiazine tranquilizer C21H24F3N3S chiefly used to treat psychotic conditions and especially schizophrenia

Word History

Etymology

tri- + fluor- + piperazine

First Known Use

circa 1957, in the meaning defined above

Time Traveler
The first known use of trifluoperazine was circa 1957

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Cite this Entry

“Trifluoperazine.” Merriam-Webster.com Dictionary, Merriam-Webster, https://www.merriam-webster.com/dictionary/trifluoperazine. Accessed 7 Jul. 2026.

Medical Definition

: a phenothiazine tranquilizer used in the form of its hydrochloride C21H24F3N3S·HCl to treat psychotic disorders and especially schizophrenia

Note: Trifluoperazine is marketed under the trademark Stelazine.

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