How to Use isoleucine in a Sentence

isoleucine

noun
  • To do that, the researchers decided to remove isoleucine from all of the proteins in the small subunit of the ribosome.
    — ArsTechnica, 30 Apr. 2026
  • One of these designs was able to complete the isoleucine-free small subunit, with the resulting strain growing about 60 percent as fast as the unedited ones.
    — ArsTechnica, 30 Apr. 2026
  • Three specific essential amino acids—leucine, isoleucine, and valine—are called Branched-Chain Amino Acids.
    — Shimite Obialo, Forbes.com, 26 May 2026
  • But that does indicate that 17 of them got by ok without isoleucine, including one where it was swapped out in 45 different positions along the amino acid chain.
    — ArsTechnica, 30 Apr. 2026
  • Redesigning the ribosome To give their project a focus, the researchers decided to start engineering an isoleucine-free ribosome.
    — ArsTechnica, 30 Apr. 2026
  • The team then focused on the 32 genes with reduced fitness and adapted deep-learning protein-design software to suggest alternative sequences that did not include isoleucine.
    — ArsTechnica, 30 Apr. 2026
  • As a preliminary test, the team did an isoleucine-to-valine swap for 50 different individual genes that contribute proteins to the ribosome.
    — ArsTechnica, 30 Apr. 2026
  • Wang and his colleagues purged 382 isoleucine residues from ribosomal proteins, but the rest of its genome still contains more than 81,000 isoleucine residues across thousands of other proteins.
    — Jacek Krywko, Scientific American, 30 Apr. 2026
  • The cells were grown 400 generations and typically picked up 20–30 mutations, but none of those restored an isoleucine to any of the ribosomal proteins.
    — ArsTechnica, 30 Apr. 2026
  • These amino acids include histidine, isoleucine, leucine, lysine, methionine, phenylalanine, threonine, tryptophan and valine – collectively necessary for building muscle, producing enzymes and hormones and maintaining healthy tissue.
    — Daryl Austin, USA Today, 21 Mar. 2026
  • In one case, while redesigning a ribosomal protein called RpsJ, the AI remodeled an alpha helix—a structural element bridging different parts of the ribosome—and introduced eight new nearby mutations to compensate for the substitution of just two isoleucines.
    — Jacek Krywko, Scientific American, 30 Apr. 2026

Some of these examples are programmatically compiled from various online sources to illustrate current usage of the word 'isoleucine.' Any opinions expressed in the examples do not represent those of Merriam-Webster or its editors. Send us feedback about these examples.

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