How to Use mitragynine in a Sentence

mitragynine

noun
  • The leaves contain a compound called mitragynine.
    — Sean Timberlake, Sacbee.com, 3 June 2026
  • After kratom is consumed, some of the mitragynine is changed in the body into 7OH.
    — Andrew Kolodny, The Conversation, 2 Apr. 2026
  • Those were refined to feature a chemical called mitragynine.
    — Teri Sforza, Oc Register, 1 May 2026
  • Those were refined to feature a chemical called mitragynine.
    — Teri Sforza, Oc Register, 8 May 2026
  • In small doses, mitragynine has a mild stimulant effect.
    — Sean Timberlake, Sacbee.com, 3 June 2026
  • Yes, evidence suggests that 7-OH is more potent than mitragynine.
    — Kevin Sabet, MSNBC Newsweek, 29 Aug. 2025
  • In fact, mitragynine, which is found in small amounts in kratom, partially stimulates opioid receptors in the central nervous system.
    — David Kroll, The Conversation, 29 Aug. 2025
  • In the body, the small amount of mitragynine in kratom powder is converted to 7-OH by liver enzymes, hence the opioid-like effects in the body.
    — David Kroll, The Conversation, 29 Aug. 2025
  • The most abundant of the psychoactive alkaloids in kratom are mitragynine and speciociliatine, Smith said.
    — Kristen Rogers, CNN Money, 26 Aug. 2025
  • Among them are psychoactive compounds mitragynine and 7-OH, which glom onto opioid receptors in the brain.
    — Claire Bugos, Verywell Health, 14 Aug. 2025
  • Agalopol currently takes a 75-milligram dose of mitragynine, the primary alkaloid in kratom, when necessary.
    — Karen Garcia, Los Angeles Times, 4 Mar. 2026
  • This matters because mitragynine is a weak opioid, while 7OH is a much stronger opioid, which can increase the intensity of the opioid effects and lead to overdose.
    — Andrew Kolodny, The Conversation, 2 Apr. 2026
  • Lobbyists are quick to say only 7-OH is responsible, but early research indicates mitragynine has also played a role.
    — Kevin Sabet, MSNBC Newsweek, 29 Aug. 2025
  • In animal testing, mitragynine was shown to have one quarter the potency of morphine; 7-hydroxymitragynine was 13 times more potent than morphine.
    — Sean Timberlake, Sacbee.com, 3 June 2026
  • Naroditsky’s concentrations of methamphetamine and mitragynine, the primary active chemical in kratom, were not by themselves fatal, according to the report.
    — Joe Marusak, Charlotte Observer, 21 Jan. 2026
  • Traces of 7-hydroxymitragynine and mitragynine were also discovered in Naroditsky's system, both of which are known to be common ingredients in the opioid-like drug kratom.
    — Zoey Lyttle, PEOPLE, 20 Jan. 2026
  • Kratom’s effects come from compounds in its leaves, including mitragynine and 7-hydroxymitragynine, often called 7OH.
    — Andrew Kolodny, The Conversation, 2 Apr. 2026
  • According to him, high concentrations of 7-hydroxymitragynine bind with the body’s mu opioid receptors much more effectively than mitragynine, which can cause dependency.
    — Sean Timberlake, Sacbee.com, 3 June 2026
  • This is because the two major ingredients, mitragynine and 7-hydroxymitragynine, have major psychoactive effects.
    — Josh Kelly, Oklahoman, 26 Mar. 2026
  • Methamphetamine and amphetamine are synthetic stimulants, while 7-hydroxymitragynine and mitragynine are major psychoactive ingredients found in kratom, a supplement that can be used as a stimulant.
    — Mirna Alsharif, NBC news, 20 Jan. 2026
  • The medical examiner determined her death was due to the effects of mitragynine, 7-hydroxymitragynine, quetiapine and mirtazapine.
    — Clara Harter, Los Angeles Times, 21 Mar. 2026
  • The Tarrant County medical examiner said Hamilton’s accidental death was due to mitragynine toxicity, one of the active ingredients of kratom.
    — Paul Flahive, Austin American Statesman, 1 Apr. 2026
  • But products sold in Missouri and elsewhere vary widely in potency, and some contain elevated levels of mitragynine and especially 7-OH — compounds that activate the brain’s opioid receptors.
    — David Hudnall, Kansas City Star, 21 Nov. 2025
  • In the body, mitragynine metabolizes into 7-hydroxymitragynine, an alkaloid commonly known as 7-OH.
    — Kristen Rogers, CNN Money, 27 Mar. 2026
  • In the body, mitragynine metabolizes into 7-hydroxymitragynine, an alkaloid commonly known as 7-OH.
    — Kristen Rogers, CNN Money, 26 Aug. 2025
  • Sanders and other 7-OH manufacturers extract mitragynine — the main active alkaloid in kratom — and chemically convert it into 7-OH, which is far more potent and addictive.
    — Kansas City Star, 16 Sep. 2025
  • The Medical Examiner deemed her death a suicide from the effects of mitragynine, 7-hydroxymitragynine, quetiapine, and mirtazapine.
    — Matthew Rodriguez, CBS News, 21 Mar. 2026
  • Smith, the leading kratom researcher, has said the emphasis on semisynthetic 7-OH is odd because there is no evidence justifying it, and because the natural kratom alkaloid mitragynine still converts to 7-OH during manufacturing and in the body.
    — Kristen Rogers, CNN Money, 27 Mar. 2026
  • National Institutes of Health announced that the agency, along with researchers from the University of Florida, would begin clinical trials on mitragynine, the primary psychoactive compound in kratom, to evaluate its potential as a treatment for opioid use disorder.
    — Karen Garcia, Los Angeles Times, 19 June 2026
  • Naroditsky had methamphetamine, amphetamine, 7-hydroxymitragynine and mitragynine in his system at the time of death, according to a toxicology report provided to NBC News by the North Carolina Office of the Chief Medical Examiner.
    — Mirna Alsharif, NBC news, 20 Jan. 2026

Some of these examples are programmatically compiled from various online sources to illustrate current usage of the word 'mitragynine.' Any opinions expressed in the examples do not represent those of Merriam-Webster or its editors. Send us feedback about these examples.

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