estrogen

noun

es·​tro·​gen ˈe-strə-jən How to pronounce estrogen (audio)
: any of various natural steroids (such as estradiol) that are formed from androgen precursors, that are secreted chiefly by the ovaries, placenta, adipose tissue, and testes, and that stimulate the development of female secondary sex characteristics and promote the growth and maintenance of the female reproductive system
also : any of various synthetic or semisynthetic steroids (such as ethinyl estradiol) that mimic the physiological effect of natural estrogens

Examples of estrogen in a Sentence

Recent Examples on the Web
Examples are automatically compiled from online sources to show current usage. Read More Opinions expressed in the examples do not represent those of Merriam-Webster or its editors. Send us feedback.
Hormones such as estrogen and thyroid hormone are chemical messengers that regulate growth, metabolism, reproduction and many other essential functions through the endocrine system. Brad Reisfeld, The Conversation, 6 July 2026 According to the outlet, Howlett said she and Julie Howlett had been married for four years and were both transitioning to female while taking estrogen and progesterone. Stepheny Price, FOXNews.com, 2 July 2026 It has been thought that hormone-replacement therapy puts women at risk for breast cancer, but newer data suggests that this is not necessarily true, and one form of estrogen seems to be associated with a decrease in breast cancer. Hannah Jocelyn, New Yorker, 1 July 2026 IUDs are also an option, as well as therapies that combine estrogen with progestin, such as pills or patches. Cathy Nelson, Health, 1 July 2026 See All Example Sentences for estrogen

Word History

Etymology

estrus + -o- + -gen

Note: The word estrogen was originally a U.S. brand name for an extract of glandular tissue used in the treatment of ovarian dysfunction. Its producer, Parke, Davis and Company, relinquished rights to the name in 1936.

First Known Use

1927, in the meaning defined above

Time Traveler
The first known use of estrogen was in 1927

Browse Nearby Words

Cite this Entry

“Estrogen.” Merriam-Webster.com Dictionary, Merriam-Webster, https://www.merriam-webster.com/dictionary/estrogen. Accessed 7 Jul. 2026.

Kids Definition

estrogen

noun
es·​tro·​gen ˈes-trə-jən How to pronounce estrogen (audio)
: a substance that tends to cause the development of secondary sex characteristics in the female and promote the growth and normal functioning of the female reproductive system
estrogenic
ˌes-trə-ˈjen-ik
adjective

Medical Definition

estrogen

noun
es·​tro·​gen ˈes-trə-jən How to pronounce estrogen (audio)
variants or chiefly British oestrogen
: any of various natural steroids (as estradiol) that are formed from androgen precursors, that are secreted chiefly by the ovaries, placenta, adipose tissue, and testes, and that stimulate the development of female secondary sex characteristics and promote the growth and maintenance of the female reproductive system
also : any of various synthetic or semisynthetic steroids (as ethinyl estradiol) that mimic the physiological effect of natural estrogens
estrogen-like adjective
or estrogenlike
an estrogen-like compound
estrogen-like effects

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